Peptides encoded by mitochondrial DNA that protect cellular energy production.
Mitochondrial-derived peptide (16 amino acids)
MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene in mitochondrial DNA. Discovered in 2015 by Dr. Changhan Lee's lab at USC, it is the first mitochondrial-encoded peptide shown to act as a signaling molecule regulating metabolism.
Tetrapeptide (modified)
SS-31 (Elamipretide) is a synthetic tetrapeptide that selectively targets cardiolipin in the inner mitochondrial membrane. It is one of the most clinically advanced mitochondria-targeted peptides.
Peptides encoded by mitochondrial DNA that protect cellular energy production.
Mitochondrial Peptides are classified based on their amino acid length, structure, origin, and biological function. This categorization helps researchers understand their potential roles and compare them to related molecules.