Epitalon / Epithalone
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).
Amino Acid Sequence
Ala-Glu-Asp-GlyAn interactive map of key discoveries, clinical trials, and major findings across 7 research milestones.
Professor Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology developed Epithalon (Ala-Glu-Asp-Gly) as a synthetic analog of the pineal gland extract epithalamin.
Timeline compiled from published research literature for educational reference. Dates reflect first major publication or event; subsequent research continues to refine findings.
Epithalon is a lab-made copy of a tiny protein your pineal gland (a pea-sized gland deep in your brain) naturally produces. Think of your DNA like a shoelace — at the tips of each shoelace are protective caps called telomeres. Every time a cell divides, these caps get a little shorter. Epithalon is studied because research suggests it may activate an enzyme called telomerase, which helps maintain these protective caps.
Epithalon is hypothesized to activate telomerase — the enzyme responsible for adding protective telomere sequences to chromosome ends. Research suggests it may also stimulate melatonin production from the pineal gland and modulate neuroendocrine function. Its effects on telomerase are thought to be mediated through interactions with the pineal gland and downstream hormonal signaling.
Some human studies were conducted by Professor Vladimir Khavinson and colleagues in Russia, examining epithalamin (the natural precursor) in elderly subjects. Published results reported observations related to melatonin production and biomarkers of aging.
Extensive animal research in rodent models. Studies have examined its effects on telomerase activity, lifespan, tumor incidence, and neuroendocrine function in aging animals.
In vitro studies have demonstrated telomerase activation in human somatic cells treated with Epithalon. Cell culture experiments have shown effects on cell proliferation capacity.
Epithalamin is the natural peptide extract from the pineal gland. Epithalon (Ala-Glu-Asp-Gly) is the synthetic, purified tetrapeptide version that was designed to replicate the key bioactive component of epithalamin.
Epithalon was developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology in Russia as part of his decades-long research into bioregulatory peptides.
As a short tetrapeptide, Epithalon is relatively stable in lyophilized form. Store at -20°C. Reconstituted solutions should be used promptly.
Research Use Only
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).