Thymosin Beta-4 Fragment
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).
Amino Acid Sequence
LKKTETQ (active fragment)An interactive map of key discoveries, clinical trials, and major findings across 8 research milestones.
Thymosin Beta-4 was first isolated from the thymus gland by Goldstein and colleagues. It was initially studied for immune-related roles before its broader functions were recognized.
Timeline compiled from published research literature for educational reference. Dates reflect first major publication or event; subsequent research continues to refine findings.
Think of TB-500 as the lab-made twin of a protein your body already makes called Thymosin Beta-4. This protein is like a construction foreman — it tells cells where to go and helps coordinate the repair process when tissue is damaged. Scientists make TB-500 in the lab so they can study exactly how this repair signaling works.
TB-500/Tβ4 is hypothesized to promote cell migration by sequestering actin (a structural protein inside cells) and modulating its polymerization. This is thought to facilitate cellular movement to sites of injury. It also appears to promote angiogenesis and reduce inflammation through downregulation of inflammatory cytokines.
Some human studies and clinical trials have been conducted, particularly in wound healing and ophthalmology (eye healing). Results have been published in peer-reviewed journals examining its effects on dermal wound repair.
Extensive research in rodent and equine (horse) models. Animal studies have explored its effects on cardiac tissue repair after injury, skin wound healing, muscle repair, and inflammatory responses.
Well-characterized mechanism of action in cell culture. Extensively studied for actin-binding properties and effects on cell migration, proliferation, and differentiation.
TB-500 is a synthetic peptide that is functionally similar to the naturally occurring Thymosin Beta-4 (Tβ4). While they share the same active region, TB-500 is a research-grade synthetic version.
Yes. Tβ4 is one of the most abundant intracellular peptides in the human body. It is found in nearly all cell types and plays a fundamental role in cell migration and tissue repair.
Relatively stable peptide. Lyophilized form recommended. Store at -20°C for long-term preservation.
Research Use Only
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).