Lysine-Proline-Valine
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).
Amino Acid Sequence
Lys-Pro-ValAn interactive map of key discoveries, clinical trials, and major findings across 6 research milestones.
KPV (Lys-Pro-Val) was identified as the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH), the portion responsible for many of α-MSH anti-inflammatory effects.
Timeline compiled from published research literature for educational reference. Dates reflect first major publication or event; subsequent research continues to refine findings.
KPV is a tiny peptide — just three amino acids — that comes from a larger hormone your body naturally makes called alpha-MSH. Think of it as the "active ingredient" extracted from a bigger molecule. Despite being incredibly small, research suggests this three-letter sequence may carry significant anti-inflammatory signaling capability.
KPV is hypothesized to enter cells and directly interact with inflammatory signaling pathways, particularly the NF-κB pathway, which is a master switch for inflammation. Unlike the full α-MSH molecule, KPV does not appear to activate melanocortin receptors, suggesting a receptor-independent mechanism of action.
Limited direct human trial data. Most evidence is extrapolated from α-MSH research in humans and supported by preclinical studies.
Animal studies, particularly in colitis (gut inflammation) models, have explored KPV's anti-inflammatory effects. Research in rodent models has examined oral and topical delivery routes.
Cell culture studies have demonstrated KPV's ability to reduce inflammatory markers (TNF-α, IL-6, IL-8) and inhibit NF-κB nuclear translocation in various immune cell types.
KPV is named after its three amino acids: K (Lysine), P (Proline), and V (Valine). It is the C-terminal tripeptide of alpha-MSH.
As a tripeptide, KPV is relatively small and may be susceptible to enzymatic degradation. Oral bioavailability research is ongoing.
Research Use Only
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).