Vasoactive Intestinal Peptide
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).
Amino Acid Sequence
His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂An interactive map of key discoveries, clinical trials, and major findings across 7 research milestones.
VIP was first isolated from pig intestine by Said and Mutt when investigating substances causing vasodilation. Its name reflected its intestinal origin.
Timeline compiled from published research literature for educational reference. Dates reflect first major publication or event; subsequent research continues to refine findings.
VIP is one of your body's most versatile signaling molecules. Despite its name suggesting it works only in the intestines, it is actually found throughout your brain, lungs, heart, and immune system. Think of it as a multi-purpose communication molecule — it was first discovered in the gut (hence the name) but turned out to be much more important than scientists initially thought.
VIP acts through two receptors (VPAC1 and VPAC2), which are widely distributed throughout the body. It stimulates adenylate cyclase, increasing cyclic AMP. Effects include vasodilation, smooth muscle relaxation, stimulation of water and electrolyte secretion in the gut, modulation of immune responses, and neuroprotection.
VIP is an endogenous human peptide with well-characterized physiology. Clinical studies have examined inhaled VIP for pulmonary conditions. Research has also explored VIP in chronic inflammatory response syndrome (CIRS) and sarcoidosis.
Animal models have studied VIP's roles in circadian clock regulation, immune modulation, and neuroprotection.
Extensive receptor pharmacology. Well-characterized signaling cascades. In vitro studies on immune cell modulation and neuroprotection.
VIP stands for Vasoactive Intestinal Peptide. It was named when first discovered in the intestine, but it is now known to be widely distributed throughout the body, including the brain, lungs, and immune system.
Susceptible to enzymatic degradation (DPP-IV, NEP). Half-life in plasma is approximately 1 minute. Modified analogs with improved stability are in research.
Research Use Only
For educational and research reference only. Not medical advice. Not for human or animal use. Research peptides are Research Use Only (RUO).